"Nyororororororon ahahaahaha weeeeeeeee! Ooohhhohohohohoho... AAAAAAAAAAHHH."
The Limit Chancellor is a special Big Head "Civilian" hidden near the end of Trauma Loop. It appears in the nude with a dark blue head with bright white eyes and a bright blue halo light emanating from it.
Upon starting Trauma Loop if the Limit Chancellor has not been killed the screen will display a message which reads "A malign influence strips you of power." All of the augments are immediately stripped from the player, forcing the player to attempt the mission without their special abilities. Because of the Limit Chancellor's placement near the end of the mission, the player is essentially forced to finish the mission without augments at least once.
Though reaching the Limit Chancellor requires running through the hostile bottom of Trauma Loop, the Chancellor's area itself seems to prevent enemies from entering.
When the Limit Chancellor is killed it does not reappear unless the game's save data is erased or modified, even if you restart the mission.
Be warned, killing the Limit Chancellor with the Parasonic C3 DNA Scrambler won't remove his malign influence from the stage (even if you destroy all cancerous mass), so you'll humiliatingly be required to do the whole thing again without the aid of implants.